Directions from San Francisco:
Take Highway 101 South to Highway 156 West.
Connect to Highway 1 South.
Continue through Monterey and Carmel to Big Sur.
Total distance is about 150 miles.
Directions from Los Angeles:
Take Highway 101 North to San Luis Obispo.
Connect to Highway 1 North.
Follow Highway 1 all the way to Big Sur.
Total distance is about 300 miles.